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The group had lunch at Pierluigi, and a source reported that they were all in good spirits.
Lupus is a chronic autoimmune disease with symptoms including body aches, fevers and extreme fatigue - it can also lead to kidney and heart damage.
Most recently, Selena Gomez and Bieber were spotted together in Jamaica at Justin's dad's wedding.
After she split with Bieber, Selena was rumoured to be connected to One Direction's Niall Horan for a short period of time.
In January 2016, she was spotted kissing singer The Weeknd outside a restaurant in Santa Monica, and they eventually went public with their romance after initially keeping it secret.
The Weeknd's ex-girlfriend, Victoria's Secret Model Bella Hadid, unfollowed Selena on Instagram.
“Selena and Andrea are nothing more than good friends and there’s no romance brewing between them whatsoever,” said the source.