Sedating antihistamines and
However there is no reason to believe that all 'non- sedating' antihistamines possess exactly the same low tendency to cross the blood brain barrier.The study by Mann et al 3 nicely illustrates this point of view.Typically people take antihistamines as an inexpensive, generic, over-the-counter drug that can provide relief from nasal congestion, sneezing, or hives caused by pollen, dust mites, or animal allergy with few side effects.Although people typically use the word “antihistamine” to describe drugs for treating allergies, doctors and scientists use the term to describe a class of drug that opposes the activity of histamine receptors in the body.-receptor are used to treat allergic reactions in the nose (e.g., itching, runny nose, and sneezing).
Fexofenadine's effects, alone and with alcohol, on actual driving performance.
The dichotomy between 1st and 2nd generation antihistamines was introduced in 1983 at about the time of the European registration of two drugs: terfenadine and astemizole.
The distinction was drawn by the drugs' manufactures to indicate a major pharmacological difference between these drugs and their predecessors.
The primary outcome variable of the test is standard deviation of lateral position (SDLP), a measure of 'weaving' or road tracking error.
Results of these studies show that the extend to which 2nd generation antihistamines affect SDLP varies with the drug, its dose and dosing regimen.
Relationship between occupation of cerebral H1 receptors and sedative properties of antihistamines. Arzneimittelforschung 1982; 32: 1171-1173 3 Mann RD, Pearce GL, Dunn N, Shakir S.